Chris Evans

Casey Jones (voice)

Sarah Michelle Gellar

April O'Neil (voice)

Patrick Stewart

Winters (voice)

Mako

Splinter (voice)

Zhang Ziyi

Karai (voice)

James Arnold Taylor

Leonardo (voice)

Mitchell Whitfield

Donatello / Additional Voices (voice)

Nolan North

Raphael / Nightwatcher (voice)

Mikey Kelley

Michelangelo (voice)

Laurence Fishburne

Narrator (voice)

Kevin Smith

Diner Cook (voice)

John DiMaggio

Colonel Santino (voice)